abstract：:Interstitial lung disease (ILD) is one of the most serious pulmonary complications associated with connective tissue diseases (CTDs), resulting in significant morbidity and mortality. Recently, lung ultrasound examination has appeared as a useful, feasible, non-invasive, radiation-free imaging technique with high sens...

journal_title：Clinical and experimental rheumatology

authors： Ferro F,Delle Sedie A

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To investigate the burden of systemic juvenile idiopathic arthritis (SJIA) on health-related quality of life (HRQOL) and resource use of patients and caregivers (families) on biologic therapy. METHODS:This international study assessed SJIA burden in patients on biologics, using a caregiver questionnaire and...

journal_title：Clinical and experimental rheumatology

authors： Shenoi S,Horneff G,Cidon M,Ramanan AV,Kimura Y,Quartier P,Foeldvari I,Zeft A,Lomax KG,Gregson J,Abma T,Campbell-Hill S,Weiss J,Patel D,Marinsek N,Wulffraat N

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Early arthritis clinics (EAC) aim to improve rheumatoid arthritis (RA) outcomes by tailoring treatment targeting to remission. Our aim was to analyse disease course and relevant predictors over 2 years in early arthritis; we also assessed the applicability of the "treat-to-target approach" in a real-life EAC...

journal_title：Clinical and experimental rheumatology

authors： Fanouriakis A,Papalopoulos I,Gergianaki I,Spyrou G,Erden A,Rapsomaniki P,Terizaki M,Avgoustidis N,Repa A,Kougkas N,Bertsias G,Boumpas DT,Sidiropoulos PI

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To describe differences in clinical presentation between men and women in a large group of patients with early (<3 years' duration) systemic sclerosis (SSc) according to disease subsets. METHODS:A cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research database (EUSTAR) was performe...

journal_title：Clinical and experimental rheumatology

authors： Carreira PE,Carmona L,Joven BE,Loza E,Andreu JL,Riemekasten G,Vettori S,Balbir-Gurman A,Airò P,Walker UA,Damjanov N,Matucci-Cerinic M,Ananieva LP,Rednic S,Czirják L,Distler O,Farge D,Hesselstrand R,Corrado A,Caramas

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties. The aim of this study was to evaluate the clinical significance of serum AIMP1 in patients with systemic lupus erythematosus (SLE). METHODS:Serum levels of AIMP1 were measu...

journal_title：Clinical and experimental rheumatology

authors： Ahn SS,Hong SH,Park Y,Jung SM,Song JJ,Park YB,Lee SW,Park SG

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Endothelial nitric oxide synthase (eNOS) is a type of nitric oxide synthase that mainly exists in the endothelium. It produces nitric oxide (NO) to regulate the function of endothelial cells. Endothelial dysfunction and increased NO metabolites have been shown in animal models of lupus and in lupus patients,...

journal_title：Clinical and experimental rheumatology

authors： Zhu J,Wang Z,Song G,Zhang T,Wang L,Wu F

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS). METHODS:Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were enrolled. IgG4-RD and pSS disease activity was assessed bas...

journal_title：Clinical and experimental rheumatology

authors： Akiyama M,Sasaki T,Kaneko Y,Yasuoka H,Suzuki K,Yamaoka K,Takeuchi T

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients ...

journal_title：Clinical and experimental rheumatology

authors： Abji F,Pollock RA,Liang K,Chandran V,Gladman DD

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:We aimed to assess the diagnostic accuracy of salivary gland ultrasonography (SGUS) as a single test for the detection of primary Sjögren's syndrome (pSS) and examine the prognostic factors for severe structural damage of the salivary glands based on SGUS score. METHODS:Patients with pSS (n=94) and idiopath...

journal_title：Clinical and experimental rheumatology

authors： Lee KA,Lee SH,Kim HR

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:ACA-positive/primary Sjögren's syndrome (pSS) represents a distinct overlapping entity with intermediate features in between limited systemic sclerosis (lSSc) and pSS. Few data are available on their general risk for lymphoproliferative complications, specifically regarding adverse predictors at the level of...

journal_title：Clinical and experimental rheumatology

authors： Notarstefano C,Croia C,Pontarini E,Lucchesi D,Sutcliffe N,Tappuni A,Donati V,Pitzalis C,Baldini C,Bombardieri M

更新日期：2018-05-01 00:00:00

abstract：:The formation of lymphomononuclear cell infiltrates organising as periductal infiltrates in the salivary glands of patients with primary Sjögren's syndrome (pSS) is one of the hallmarks of the disease. Historically, the clinical role of salivary gland histopathology, most commonly performed on labial salivary gland bi...

journal_title：Clinical and experimental rheumatology

authors： Kroese FGM,Haacke EA,Bombardieri M

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:The need to include patients' perspectives as key outcomes in clinical trials is widely accepted. No disease-specific patient-reported outcomes have been developed in Takayasu's arteritis. This project was designed to identify outcomes of importance to patients with Takayasu's arteritis during active disease...

journal_title：Clinical and experimental rheumatology

authors： Sreih AG,Alibaz-Oner F,Easley E,Davis T,Mumcu G,Milman N,Robson J,Direskeneli H,Merkel PA,Cronholm P

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:We estimated the cumulative patient survival rates, the causes of death and the initial predictors of death in Korean patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) and eosinophilic GPA (EGPA). METHODS:We reviewed the medical records of 153 patients with antineutrophil ...

journal_title：Clinical and experimental rheumatology

authors： Mun CH,Yoo J,Jung SM,Song JJ,Park YB,Lee SW

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Antibodies directed to citrullinated proteins are highly specific for rheumatoid arthritis (RA). Citrullination is catalyzed by peptidylarginine deiminase (PAD) enzymes. The current study examined the mRNA expression of PADI2 and PADI4 in bone marrow (BM) CD34+ cells from RA patients. METHODS:CD34+ cells we...

journal_title：Clinical and experimental rheumatology

authors： Nagai T,Matsueda Y,Tomita T,Yoshikawa H,Hirohata S

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:The eumusc.net standards of care (SOCs) for rheumatoid arthritis (RA) aimed to improve quality of care across Europe. This study investigated importance and implementation of each standard according to patients and health care professionals (HCPs) in the Netherlands and identified barriers towards implementa...

journal_title：Clinical and experimental rheumatology

authors： Hifinger M,Ramiro S,Putrik P,van Eijk-Hustings Y,Woolf A,Smolen JS,Stoffer-Marx M,Uhlig T,Moe RH,Saritas M,Janson M,van der Helm-van Mil A,van de Laar M,Vonkeman H,de Wit M,Boonen A

更新日期：2018-03-01 00:00:00

abstract：:Patients with rheumatoid arthritis are at greater risk of infectious morbidity and mortality due to disease-related abnormalities and use of immunosuppressive medications. Vaccinations are recommended by international guidelines among infection control strategies, but vaccination rates are reported to be still subopti...

journal_title：Clinical and experimental rheumatology

authors： Meroni PL,Zavaglia D,Girmenia C

更新日期：2018-03-01 00:00:00

abstract：:Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory pro...

journal_title：Clinical and experimental rheumatology

authors： Scarpioni R,Obici L

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the relationship between serum infliximab (IFX) levels and changes of RF and ACPA levels in patients with rheumatoid arthritis (RA). METHODS:Enzyme-linked immunosorbent assays (ELISA) [Promonitor® IFX R1 (version 2) (Progenika Biopharma, Spain)] were used to measure ...

journal_title：Clinical and experimental rheumatology

authors： Martínez-Estupiñán L,Hernández-Flórez D,Janta I,Ovalles-Bonilla JG,Nieto JC,González-Fernández CM,Del Río T,Monteagudo I,López-Longo FJ,Naredo E,Valor L

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Osteoarthritis (OA) is a common degenerative disease of the synovial joints. Although numerous studies have been performed, the aetiology of OA remains unclear. Evidence suggests that DNA methylation plays important roles in OA. METHODS:Integrated analysis of five gene expression and one methylation profili...

journal_title：Clinical and experimental rheumatology

authors： Fan Y,Chen J,Yang Y,Lin J,Wu Z

更新日期：2017-11-01 00:00:00

abstract：:Olfaction plays an important role in the perception of our environment. Smell impairment is known to be a manifestation of several autoimmune diseases. Similarities between the olfactory and immune systems and previously published human studies and animal models of autoimmune diseases account for the accumulating evid...

journal_title：Clinical and experimental rheumatology

authors： Shamriz O,Shoenfeld Y

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To assess adherence to published guidelines for the treatment of Behçet's syndrome (BS) in two geographic areas. METHODS:We extracted guideline statements from the 2008 EULAR recommendations. Adherence to these statements was evaluated retrospectively in both New York (USA) and Amsterdam (The Netherlands), ...

journal_title：Clinical and experimental rheumatology

authors： Kerstens FG,Turkstra F,Atalay S,van Vugt RM,Swearingen CJ,Yazici Y

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Familial Mediterranean fever (FMF) is characterised by recurrent attacks of fever and serositis. It may affect the peritoneum, pleura, synovia and the skin. Usually the liver is intact in FMF. Recently, this concept was challenged by some groups which claimed that hepatitis is a feature of FMF and that non-a...

journal_title：Clinical and experimental rheumatology

authors： Ben-Chetrit E,Yazici H

更新日期：2017-11-01 00:00:00

abstract：:Every year new concepts about pathogenesis, serology, diagnosis and treatment in inflammatory myopathies (IIMs) have been provided. The purpose of this manuscript is to summarise the most relevant literature contributions published over the last year about these complex and rare diseases. ...

journal_title：Clinical and experimental rheumatology

authors： Barsotti S,Bruni C,Cometi L,Valentini V,Cioffi E,Neri R,Cavagna L

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To describe the effectiveness and safety of tocilizumab (TCZ), an interleukin-6 receptor inhibitor, in a cohort of patients with rheumatoid arthritis (RA) recruited in clinical practice. METHODS:TRUST was an observational study in RA patients who started treatment with TCZ in the 6 months prior to site acti...

journal_title：Clinical and experimental rheumatology

authors： Caporali R,Idolazzi L,Bombardieri S,Ferraccioli G,Gerli R,Govoni M,Matucci Cerinic M,Pomponio G,Salaffi F,Tirri R,Benaglio F,Bianchino L,Sarzi-Puttini P,TRUST study investigators.

更新日期：2017-11-01 00:00:00

abstract：:A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome m...

journal_title：Clinical and experimental rheumatology

authors： Hatemi G,Seyahi E,Fresko I,Talarico R,Hamuryudan V

更新日期：2017-11-01 00:00:00

abstract：:The lack of successful translation of basic research discoveries into safe and effective treatments for chronic pain patients has led to increased scrutiny of the preclinical models used in pain research, particularly for osteoarthritis, where there is a significant disconnect between the animal models used to study t...

journal_title：Clinical and experimental rheumatology

authors： Cimino Brown D

更新日期：2017-09-01 00:00:00

abstract：:Blockade of nerve growth factor (NGF) with antibodies is a promising strategy for treatment of chronic pain associated with osteoarthritis (OA). This narrative review describes the current status of NGF-blockade for the treatment of OA pain. We summarise briefly current evidence for the efficacy and risks of anti-NGF ...

journal_title：Clinical and experimental rheumatology

authors： Miller RE,Malfait AM,Block JA

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Prompted by the few studies available in the literature, we analysed patients with necrotising myopathy associated with anti-signal recognition particle (anti-SRP). METHODS:We conducted a retrospective, single-centre cohort study involving 14 patients with anti-SRP antibody followed between 2001 and 2016. ...

journal_title：Clinical and experimental rheumatology

authors： De Souza FHC,Miossi R,Shinjo SK

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:The CD40L/CD40 pathway is involved in the pathophysiology of atherothrombotic disease, and elevated levels of soluble CD40L (sCD40L) were reported in SLE patients. However, the clinical implication of sCD40L in SLE remains elusive. METHODS:We measured levels of plasma sCD40L in 241 SLE patients and 37 healt...

journal_title：Clinical and experimental rheumatology

authors： Kim KJ,Baek IW,Yoon CH,Kim WU,Cho CS

更新日期：2017-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately affects women. It is characterised by a broad spectrum of clinical manifestations, however, its course and organ involvement are unpredictable. Although over the last few decades an improvement in survival for SLE patients has been o...

journal_title：Clinical and experimental rheumatology

authors： La Paglia GMC,Leone MC,Lepri G,Vagelli R,Valentini E,Alunno A,Tani C

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of and risk factors for avascular necrosis (AVN) in systemic lupus erythematosus (SLE). METHODS:MEDLINE, CINAHL, Web of Science, EMBASE and Cochrane Library were searched from inception to July, 2015 and a random effects model was used to combine frequencies; study quality was as...

journal_title：Clinical and experimental rheumatology

authors： Nevskaya T,Gamble MP,Pope JE

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to compare the discontinuation rates of tofacitinib and biologics (tumour necrosis factor inhibitors (TNFi), abatacept, rituximab, and tocilizumab) in rheumatoid arthritis (RA) patients considering inadequate responses (IRs) to previous treatment(s). METHODS:Randomised controll...

journal_title：Clinical and experimental rheumatology

authors： Park SK,Lee MY,Jang EJ,Kim HL,Ha DM,Lee EK

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The characteristics of T cells targeted by abatacept (ABT) in cases of rheumatoid arthritis (RA) are still unknown. The goal of the study was to determine the pathogenicity of T cells and the predictors of therapeutic effects of ABT. METHODS:We analysed the peripheral T cell phenotype of 34 RA patients via ...

journal_title：Clinical and experimental rheumatology

authors： Fukuyo S,Nakayamada S,Iwata S,Kubo S,Saito K,Tanaka Y

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection....

journal_title：Clinical and experimental rheumatology

authors： Papa R,Consolaro A,Minoia F,Caorsi R,Magnano G,Gattorno M,Ravelli A,Picco P

更新日期：2017-05-01 00:00:00

abstract：:Pain is one of the most frequent clinical symptoms encountered by orthopaedic surgeons and rheumatologists as it is one of the main reasons for patients seeking medical help. Traumas and/or inflammatory rheumatologic diseases give rise to two different types of acute pain, but their chronic evolution is so similar tha...

journal_title：Clinical and experimental rheumatology

authors： Masala IF,Caso F,Sarzi-Puttini P,Salaffi F,Atzeni F

更新日期：2017-05-01 00:00:00

abstract：:Ultrasound (US) has acquired an increasing role in the assessment of joint and periarticular abnormalities in osteoarthritis (OA). It is able to image a large set of abnormalities in this disease which include both inflammatory and structural changes at different peripheral joint sites and it is helpful in guiding loc...

journal_title：Clinical and experimental rheumatology

authors： Iagnocco A,Naredo E

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To determine if experienced health care providers (HCPs) can recognise patients with fibromyalgia (FM) based on a limited set of personality items, exploring the existence of a FM personality. METHODS:From the 240-item NEO-PI-R personality questionnaire, 8 HCPs from two different countries each selected 20 ...

journal_title：Clinical and experimental rheumatology

authors： Da Silva JAP,Jacobs JWG,Branco JC,Canaipa R,Gaspar MF,Griep EN,van Helmond T,Oliveira PJ,Zijlstra TJ,Geenen R

更新日期：2017-05-01 00:00:00

abstract：: ...

journal_title：Clinical and experimental rheumatology

authors： Onur H,Kasapcopur O

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:We sought to determine the prevalence and clinical and laboratory associations of fibromyalgia in adults with primary immunodeficiency (immunoglobulin (Ig) G subclass deficiency (IgGSD) and common variable immunodeficiency (CVID). METHODS:We performed a retrospective analysis of these observations in 300 no...

journal_title：Clinical and experimental rheumatology

authors： Barton JC,Bertoli LF,Barton JC,Acton RT

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We evaluated the efficacy and safety of tofacitinib 5 or 10 mg twice daily (BID), in patients with moderate to severe RA, aged ≥65 and <65 years. METHODS:Data were pooled from five Phase 3 trials and, separately, f...

journal_title：Clinical and experimental rheumatology

authors： Curtis JR,Schulze-Koops H,Takiya L,Mebus CA,Terry KK,Biswas P,Jones TV

更新日期：2017-05-01 00:00:00